The Cathedral of St. Patrick ) is a decorated Neo-Gothic-style Roman Catholic cathedral church.

The cathedral was designed by James Renwick, Jr. in the Gothic Revival style. On August 15, 1858, the cornerstone was laid, just south of the diocese's orphanage. At that time, present-day midtown Manhattan was far north of the populous areas of New York City.

Work began in 1858 but was halted during the Civil War and resumed in 1865. The cathedral was completed in 1878 and dedicated on May 25, 1879, its huge proportions dominating the midtown of that time.