The chapel, on the north side of Roskilde cathedral, is the only remnants of the many medieval chapels that were attached to the original cathedral. St Andrew's chapel was constructed in 1396.
St Andrew's chapel was completely redecorated in 2010 by artist Peter Brandes, who provided a new altarpiece as well as a latticework separating the chapel from the nave. It is the intention of the parochial church council that in future the chapel will provide a more intimate setting for some of the church functions in the cathedral, such as weddings or baptisms.